Akt sex

Duration: 14min 49sec Views: 761 Submitted: 29.09.2020
Category: Squirt
Tags: akt+sex
Sex differences in the incidence of depression and antidepressant treatment responses are well documented. Depression is twice as common in women as in men. Recent studies indicate that low levels of leptin, an adipocyte-derived hormone, are associated with increased symptoms of depression in women. Leptin has been shown to produce antidepressant-like effects in male rodents. In the present study, we examined sex differences and estrous cycle variations in antidepressant-like responses to leptin.

Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt

Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt

Met 5 -enkephalin ME -induced cardioprotection occurs via epidermal growth factor receptor EGFR transactivation with the subsequent activation of phosphatidylinositol 3-kinase PI3K. In the present study, we investigated whether there is a sex difference in ME-elicited PI3K signaling. Cell death was assessed by propidium iodide. More than cells were examined for each treatment. There was not a sex difference in the basal content of total Akt. ME microM elicited comparable protection in both sexes. Wortmannin and the nonselective Akt inhibitor IV completely abolished ME-induced protection in male cardiomyocytes but only attenuated protection in female cardiomyocytes.

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